Developed computational models to evaluate changes in compartmental volumes and pressures over time, simulating cardiac function with and without C-Pulse support.
Analyzed phase angle effects on aortic pressure dynamics, optimizing timing for C-Pulse activation to enhance cardiac output and perfusion.
What I Did
Demonstrated improved cardiac output and perfusion pressure across varying sickness factors, showcasing the efficacy of the C-Pulse device in supporting failing circulation.
Evaluated C-Pulse device performance as a less invasive "bridge to transplant" alternative to LVADs, identifying its potential to improve longterm patient outcomes
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When electrical signals conducted by the Purkinje system of fibers are blocked, the heart cannot properly pump blood, potentially leading to heart dilation and failure. The current device used to support heart failure patients is the left ventricular assist device (LVAD). The severity and invasiveness of LVAD implant surgery is greater than that of C-Pulse implants. This report investigates the potential effectiveness of a new “bridge to transplant” device to support failing blood circulation in patients with profound heart failure and improve patient outcomes.
Discussion:
Results demonstrate that the cardiac perfusion pressure for different sickness factors is higher with the use of C-Pulse. The cardiac output for different sickness factors is lower without the use of C-Pulse, and this can be seen across all sickness factors. Overall, the C-Pulse increases cardiac output, blood pressure, and coronary perfusion pressure in comparison to cases where the C-Pulse is off. In accordance with these findings, the C-Pulse device to be used as a safe, preferred alternative ventricular assist device compared to other devices on the market currently (like LVAD implant and related surgery complications) to keep the patient alive long-term until a suitable donor heart becomes available.
